Clinical effect of alprostadil combined with Kudiezi injection in the treatment of posterior circulation ischemic vertigo and its effect on levels of Iysophosphatidic acid, acidic phospholipid / 中国基层医药

Objective To explore the clinical effect of alprostadil combined with Kudiezi injection in the treatment of posterior circulation ischemic vertigo,and its effect on levels of lysophosphatidic acid (LPA),acidic phospholipid (AP).Methods From October 2015 to October 2017,92 cases of posterior circulation ischemia in the Affiliated Hospital of Medical College were selected and randomly divided into observation group(n =46) and control group(n =46) according to the digital table.The control group was treated with Kudiezi injection,while the observation group was treated with alprostadil combined with Kudianzi injection.The clinical efficacy and LPA,AP levels before and after treatment were compared between the two groups.Results After treatment,the total effective rate in the observation group was 95.65％,which in the control group was 82.61％,there was statistically significant difference between the two groups(x2 =8.622,P ＜0.05).After treatment,Vm and Vs of bilateral vertebrobasilar artery in both two groups were increased more rapidly than those before treatment(observation group:t =14.041,11.124,11.207,10.057,10.925,11.920;control group:t =7.204,7.057,8.145,6.572,6.581,5.481,all P ＜ 0.05).Compared with the control group,the Vm [(34.24 ± 3.04) cm/s,(30.54 ± 3.33) cm/s,(35.42 ± 3.46) cm/s] and Vs[(40.09 ± 5.14) cm/s,(40.24 ± 5.02) cm/s,(43.14 ± 4.97) cm/s] of bilateral vertebrobasilar artery in the observation group were significantly higher (t =7.825,4.581,8.610,7.256,7.017,5.824,all P ＜ 0.05).After treatment,the levels of LPA and AP in the two groups were significantly lower than those before treatment(observation group:t =18.054,17.259;control group:t =17.651,14.254,all P ＜ 0.05).The levels of LPA and AP in the control group [(1.75 ± 0.52) μmol/L,(2.42 ± 0.51) μmol/L] were significantly higher than those in the observation group [[(1.05 ± 0.28) μmol/L,(1.84 ± 0.48) μmol/L] (t =8.571,7.224,all P ＜ 0.05).Before treatment,the number of white blood cells in two groups were (6.23 ±0.54) × 109/L,(6.68 ±0.57) × 109/L,respectively,which after treatment were (6.57 ±0.61) × 109/L,(6.42 ±0.64) × 109/L,respectively,there was no statistically significant difference in leukocyte count between the two groups before and after treatment(all P ＜ 0.05).During the treatment,there was no obvious adverse reaction in the two groups.Conclusion Alprostadil combined with Kudiezi injection in the treatment of circulatory ischemic vertigo has excellent clinical effect,there are no adverse reactions such as leukopenia occurred and the safety is good.

Effects of levofloxacin on serum CRP and WBC in community-acquired pneumonia / 中国生化药物杂志

Objective To investigate the effects of levofloxacin in the treatment of community-acquired pneumonia and the influence on serum levels of c-reactive protein(CRP)and white blood cell(WBC).Methods 60 patients with community acquired pneumonia from January 2010 to December 2013 in Affiliated Hospital of Ningbo University Medical College were selected and divided into control group(n=30)and research group(n=30),the control group was treated with amoxicillin potassium clavulanate joint azithromycin,the research group was treated with levofloxacin,the clinical effect,clinical symptoms disappear time,CRP,WBC,immune function and safety of two groups were compared.Results There was no significant difference in the efficiency of the two groups.The fever,cough and lung wet rale disappearing time of research group was(3.23±0.48)d,(7.84±1.12)d,(8.26±1.18)d,less than the control group(4.69±0.66)d,(9.30±1.34)d,(9.87±1.43)d,the difference was statistically significant(P<0.05).After treatment,the CRP,WBC of research group was(29.54±4.15)mg/L,(7.11±1.10)×109/L,lower than the control group(36.41±5.17)mg/L,(8.25±1.15)×109/L,the difference was statistically significant(P<0.05).The immune function of research group was improved more significantly than control group,the difference was statistically significant(P<0.05).There was no significant difference in safety between the two groups.Conclusion The effect is reliable of levofloxacin treatment of community-acquired pneumonia,and can decrease the serum level of CRP and WBC.

Antimicrobial Resistance of Acinetobacter baumannii and Clinical Strategies / 中华医院感染学杂志

OBJECTIVE To analyze the antimicrobial resistance of Acinetobacter baumannii.METHODS A.baumannii was collected in our hospital from Jan 2003 to Dec 2006.Antimicrobial susceptibility testing was performed by disk-diffusion method.RESULTS A total of 548 A.baumannii were collected during 4 years.Of these isolates,130(23.7%) strains were from intensive care unit(ICU),190 strains(34.7%)from surgical,and others from medical and emergency departments.Most of strains(78.5%) were isolated from sputum,next from wound.The prevalence of A.baumannii was increasing during last 4 years.Results of susceptibility test showed that imipenem was the most active antibiotic against A.baumannii.The resistance rates were high to most antibiotics.Most of the resistant strains was from the ICU and the general ward differentand had significant difference.More than 50% of isolates were resistant to all antimicrobial agents tested except imipenem and ciprofloxacin in ICU.CONCLUSIONS The prevalence of A.baumannii is increasing.A.baumannii isolates show high resistance to multiple antibiotics,especially in ICU.